An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p Fagonia cretica is a species of plant in the Zygophyllaceae, the Caltrop family, specifically the fagonbushes. It is found in Alicante province, Spain, the Balearic. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with.
|Published:||20 September 2014|
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This will fagonia cretica to cover some expenses needed to maintain the website and its further development. Further investigation into the mode of fagonia cretica revealed that extract treatment induced cell cycle arrest and apoptosis in both MCF-7 and MDA-MB cell lines.
Furthermore, inhibition of extract-induced p53 expression with siRNA reduced the fagonia cretica effect against MCF-7 cells. Isolation and characterisation of the active compound s within the extract was attempted using liquid chromatography and mass spectrometry in conjunction with a cell viability assay.
Multiple fractionations generated an active fraction that fagonia cretica four major compounds as detected by mass spectrometry. However, loss of cell viability was only partly due to a pdriven response; as MDA-MB and pknockdown MCF-7 cells both underwent cell cycle arrest and death following extract treatment.
Fagonia cretica results demonstrate for the first time that an aqueous extract of Fagonia cretica can induce cell cycle arrest and apoptosis via pdependent and independent mechanisms, with activation fagonia cretica the DNA damage response.